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NR (Nicotinamide Riboside)

Also known as NR

Half-life

~2 hours

What is NR (Nicotinamide Riboside)?

NAD+ precursor. Converts to NMN then NAD+ in cells. Well-researched with multiple human trials.

How NR (Nicotinamide Riboside) works

Enters cells and is phosphorylated to NMN, then converted to NAD+ via NMNAT. Tru Nivagen (Tru Niagen) form has extensive human safety data showing dose-dependent NAD+ elevations.

Benefits & uses

  • Raises NAD+ (well-documented in humans)
  • Cellular energy
  • Metabolic support
  • Longevity interest

Common uses: NAD+ replenishment, energy metabolism, DNA repair, mitochondrial function, longevity.

Longevity

NR (Nicotinamide Riboside) dosage

Typical dose
250–300 mg twice daily. Niagen (Chromadex) has most clinical research.

NR (Nicotinamide Riboside) half-life

~2 hours (NR in plasma)

NR (Nicotinamide Riboside) side effects

Very safe in clinical trials. GI upset in some. More studied than NMN in humans.

  • Generally very safe
  • Mild GI discomfort in some
  • Costly per dose
  • Generally well tolerated (12-month human safety data)

Commonly stacked with

PterostilbeneResveratrolTMG (Trimethylglycine)

Track NR (Nicotinamide Riboside) in Protokol.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.