SupplementEmergingLongevity

NMN (Nicotinamide Mononucleotide)

Also known as NMN

Half-life

~15–20 minutes

What is NMN (Nicotinamide Mononucleotide)?

NAD+ precursor with strong preclinical data on aging, energy, and mitochondrial function.

How NMN (Nicotinamide Mononucleotide) works

Directly converted to NAD+ in cells via NMN adenylyltransferase (NMNAT). Rising NAD+ activates sirtuins (SIRT1–7) and PARPs for DNA repair, mitochondrial biogenesis, and metabolic regulation.

Benefits & uses

Raises NAD+ levels
Cellular energy/metabolism
Improved insulin signaling (early human data)
Longevity interest

Common uses: NAD+ replenishment, mitochondrial function, DNA repair, energy, longevity potential.

Longevity

NMN (Nicotinamide Mononucleotide) dosage

Typical dose: 250–500 mg/day sublingually or oral in morning. Often combined with resveratrol for synergistic sirtuin activation.

NMN (Nicotinamide Mononucleotide) half-life

~15–20 minutes (NMN in plasma → converted to NMN in tissues)

NMN (Nicotinamide Mononucleotide) side effects

Very safe in short-term studies. Long-term effects unknown. Expensive per-dose.

Expensive
Long-term human data limited
May cause mild nausea on empty stomach
Potential to promote cancer growth in those with existing malignancies — discuss with physician
Generally well tolerated (short-term human safety data to 12 months)

Warnings & monitoring

FDA has taken a contested position on NMN's supplement status — availability may vary

NMN (Nicotinamide Mononucleotide) interactions

with Metformin
Caution · low
David Sinclair's research indicates metformin may interfere with exercise-induced longevity benefits of NAD+ precursors like NMN. Consider separating use or cycling metformin.
Timing: Evidence suggests metformin may blunt NMN's exercise performance benefits
with NAD+
Compatible
NMN is a NAD+ precursor — taking both is largely redundant but not harmful. NMN converts to NMN then NAD+. Choose one precursor and optimize dosing rather than stacking.
Timing: Morning administration for both; sublingual NMN or oral NAD+ precursors

Commonly stacked with

Resveratrol TMG (Trimethylglycine)

Track NMN (Nicotinamide Mononucleotide) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.