SupplementAnecdotalLongevity

Resveratrol

Also known as Resveratrol Trans

Half-life

~1–3 hours

What is Resveratrol?

Polyphenol found in red wine. Activates sirtuins and AMPK. Best combined with NMN.

How Resveratrol works

Direct SIRT1 activator (via AMPK) and indirect activator of AMPK. Works synergistically with NMN/NR to maximize sirtuin activity. Also activates Nrf2 antioxidant pathway and inhibits NF-kB inflammatory signaling.

Benefits & uses

Antioxidant
Sirtuin activation (mostly lab/animal)
Often co-dosed with NMN and fat for absorption
Active resveratrol isomer
Sirtuin activation (lab/animal)

Common uses: Longevity, SIRT1 activation, cardiovascular health, antioxidant, anti-inflammatory.

Longevity

Resveratrol dosage

Typical dose: 250–500 mg/day with NMN and fat-containing meal. Trans-resveratrol form superior.

Resveratrol half-life

~1–3 hours (poor bioavailability; trans form best; take with fat)

Resveratrol side effects

Very safe. High doses (>2g/day) may have mild estrogenic effects.

Mild estrogenic effects at very high doses (>2 g/day) — significant doses only
Poor oral bioavailability — use liposomal or trans form
Drug interactions with CYP450 enzymes
Generally well tolerated
GI upset at high doses
Well tolerated

Resveratrol interactions

with NAD+
Compatible
Resveratrol activates sirtuins (SIRT1) which require NAD+ as a cofactor. Synergistic longevity combination. Resveratrol may inhibit NMN absorption — space apart by 30 minutes.
Timing: Both taken in the morning; resveratrol fat-soluble — take with food