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SupplementEmergingAntioxidant

Quercetin

Half-life

~3

What is Quercetin?

Flavonoid with broad anti-inflammatory, antioxidant, and zinc ionophore properties. Synergistic with zinc against viruses.

How Quercetin works

Inhibits NF-kB, histamine release, and COX-2/5-LOX; acts as a zinc ionophore transporting zinc into cells; senolytic activity by disrupting Bcl-2 pro-survival pathways in senescent cells.

Benefits & uses

  • Senolytic (clears aged cells)
  • Anti-inflammatory
  • Allergy/immune support
  • Antioxidant

Common uses: Anti-inflammatory, zinc ionophore (immune), antiviral, senolytic, allergy relief.

LongevityRecovery

Quercetin dosage

Typical dose
500–1000 mg/day quercetin phytosome form with zinc for immune protocols. Senolytic: 1000 mg + fisetin.

Quercetin half-life

~3.5 hours (quercetin aglycone in plasma)

Quercetin side effects

Very safe. Poor bioavailability — take with bromelain or phospholipid form. Mild headache in some.

  • Poor bioavailability — use phytosome or quercetin glycoside form
  • Mild headache in some individuals
  • Drug interactions: inhibits CYP3A4 enzymes
  • Generally well tolerated
  • Headache/tingling at very high doses

Commonly stacked with

FisetinZincBromelainVitamin C (Ascorbic Acid)

Track Quercetin in Protokol.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.