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SupplementEmergingLongevity

Fisetin

Half-life

~3

What is Fisetin?

Flavonoid with the most potent senolytic (senescent cell clearing) activity among tested polyphenols.

How Fisetin works

Senolytic: selectively kills senescent cells by inhibiting pro-survival pathways (PI3K/Akt) active in 'zombie cells'. Also activates SIRT1 and inhibits NF-kB. Used in 2-5 day high-dose pulse protocols.

Benefits & uses

  • Senolytic (clears aged cells)
  • Anti-inflammatory
  • Antioxidant/neuroprotection
  • Longevity interest

Common uses: Senescent cell clearance, longevity, neuroprotection, antioxidant, anti-inflammatory.

Longevity

Fisetin dosage

Typical dose
Senolytic: 500 mg–2 g/day for 2–5 consecutive days monthly. Daily antioxidant: 100–200 mg. Take with fat.

Fisetin half-life

~3.5 hours (plasma; short half-life requires intermittent high-dose protocol)

Fisetin side effects

Generally safe at studied doses. Very poor bioavailability — take with fat.

  • Very poor oral bioavailability
  • High doses may cause mild GI discomfort
  • Drug interactions possible — avoid with anticoagulants
  • Generally well tolerated

Commonly stacked with

QuercetinDasatinib (prescription)

Track Fisetin in Protokol.

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More Longevity

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.