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SupplementEmergingLongevity

Spermidine

Half-life

~30–45 minutes

What is Spermidine?

Polyamine that declines with age. Activates autophagy — the cellular 'self-cleaning' process.

How Spermidine works

Stabilizes RNA and modulates translation, activates autophagy via inhibition of EP300 acetyltransferase, and modulates polyamine metabolism — all mechanisms linked to longevity in model organisms.

Benefits & uses

  • Induces autophagy (cellular cleanup)
  • Longevity (strong epidemiological link)
  • May support hair/cognition
  • Cardiovascular interest

Common uses: Longevity via autophagy, cardiovascular health, cognitive function, immune modulation.

Longevity

Spermidine dosage

Typical dose
1–5 mg/day from wheat germ extract or spermidine-rich foods. Clinical trials used 0.9–1.2 mg/day.

Spermidine half-life

~30–45 minutes (plasma)

Spermidine side effects

Very safe at food-equivalent doses. Naturally abundant in natto, wheat germ, legumes.

  • Generally very safe
  • GI upset at high doses in some individuals
  • Generally well tolerated

Track Spermidine in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.

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More Longevity

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.