SupplementEmergingAntioxidant

Glutathione

Also known as Glutathione (Liposomal), Glutathione (IV), Liposomal Glutathione, IV Glutathione, GSH, Glutathione IM

Half-life

~2 hours oral liposomal

What is Glutathione?

Master antioxidant, run as either oral liposomal or IV/IM. Liposomal achieves meaningful plasma levels; plain non-liposomal oral GSH is poorly absorbed and essentially useless. IV gives the highest bioavailability and is clinic-administered.

How Glutathione works

Tripeptide (gamma-glutamylcysteinylglycine) that directly neutralizes reactive oxygen species, conjugates toxins for excretion, and regenerates oxidized vitamin C and E. Liposomal encapsulation bypasses gut oxidation for systemic delivery; IV bypasses gut and liver metabolism entirely for immediate cellular uptake.

Benefits & uses

Master antioxidant
Liver/detox support
Immune support
Skin brightening (marketed)

Common uses: Antioxidant defense, liver support, immune function, skin lightening, heavy metal detox, post-cycle recovery.

LongevityRecovery

Glutathione dosage

Typical dose: Oral liposomal: 250–500 mg/day. IV/IM: 500–2000 mg IV push over 10–15 min, or IM — compounded and administered by a qualified provider.

Glutathione half-life

~2 hours oral liposomal (plasma GSH); ~10 minutes as an IV bolus — short but potent

Glutathione side effects

Oral liposomal: very safe, very expensive. IV/IM: injection risk, potential anaphylaxis, IV must be clinic-administered. Consider NAC to raise endogenous production instead.

Cost-prohibitive at high doses
Plain (non-liposomal) oral form essentially useless — use NAC for GSH synthesis instead
IV access complications
Rare anaphylaxis with IV/IM
Clinic environment required for IV administration
Otherwise well tolerated

Preparation & storage

Reconstitution: For SubQ/IM: reconstitute per product; oral liposomal needs no recon; IV is clinic-administered

Commonly stacked with

NAC (N-Acetyl Cysteine)Vitamin C (Ascorbic Acid)

Track Glutathione in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.