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TMG (Trimethylglycine)

Also known as Betaine Anhydrous, TMG

Half-life

~few hours

What is TMG (Trimethylglycine)?

Betaine / trimethylglycine — a methyl donor that supports homocysteine metabolism and methylation, often paired with NAD+ precursors to replenish methyl groups.

How TMG (Trimethylglycine) works

Donates methyl groups via betaine-homocysteine methyltransferase to remethylate homocysteine to methionine, supporting SAMe production.

Benefits & uses

  • May improve strength/power
  • Supports body composition
  • Methylation/homocysteine support
  • Cellular hydration
  • Methylation / homocysteine support
  • May support power output
  • Often paired with NMN/NR

Common uses: Homocysteine reduction, methylation support, training performance, NMN/NR methyl-buffer.

MuscleLongevity

TMG (Trimethylglycine) dosage

Typical dose
1000–2500 mg/day; pair with NMN/NR to offset methylation demand.

TMG (Trimethylglycine) half-life

~few hours (rapid renal clearance)

TMG (Trimethylglycine) side effects

  • GI upset at high doses
  • May raise total cholesterol at very high intakes
  • Fishy body odor at extreme doses
  • Well tolerated
  • Mild GI upset
  • Fishy body odor at high doses
  • Fishy odor at high doses

Commonly stacked with

NMN (Nicotinamide Mononucleotide)NR (Nicotinamide Riboside)

Track TMG (Trimethylglycine) in Protokol.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.