SupplementWell-studiedSports Performance
L-Citrulline
Half-life
~1 hour
What is L-Citrulline?
Non-essential amino acid that converts to arginine in vivo. More bioavailable than arginine supplementation.
How L-Citrulline works
Converted to arginine via the urea cycle in the gut and kidney; produces sustained arginine (and NO) levels superior to arginine supplementation itself.
Benefits & uses
- Improves blood flow / pumps
- Supports endurance
- May reduce muscle soreness
- Better NO precursor than arginine
Common uses: Nitric oxide support, vasodilation, blood flow, pump, endurance, ED support.
Muscle
L-Citrulline dosage
- Typical dose
- 6–8 g pre-workout (pure L-citrulline)
L-Citrulline half-life
~1 hour (plasma arginine from citrulline persists ~2 hours)
L-Citrulline side effects
- GI upset (rare, less than arginine)
- Minimal side effects
- Excellent tolerability
- Very well tolerated
Commonly stacked with
Track L-Citrulline in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
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