Supplement
Pterostilbene
Half-life
~7 hours
What is Pterostilbene?
Dimethyl ether of resveratrol from blueberries. Far superior bioavailability (80%) vs resveratrol (20%).
How Pterostilbene works
Methylated resveratrol analog that resists rapid metabolism, achieving significantly higher plasma levels and longer duration of SIRT1, AMPK, and Nrf2 activation. Crosses the blood-brain barrier more readily than resveratrol.
Benefits & uses
Common uses: SIRT1 activation, neuroprotection, blood sugar regulation, cardiovascular health, longevity.
Pterostilbene dosage
- Typical dose
- 50–150 mg/day. Often combined with NMN or NR for synergistic sirtuin activation.
Pterostilbene half-life
~7 hours (longer than resveratrol)
Pterostilbene side effects
High doses (>500 mg/day) may raise LDL cholesterol. Otherwise very safe.
- LDL elevation at high doses (>500 mg/day) in some studies — monitor lipids
- Otherwise extremely well tolerated
Commonly stacked with
Track Pterostilbene in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
