VitaminWell-studiedVitamin

Vitamin B12 (Hydroxocobalamin)

Also known as Vitamin B12

Half-life

~2–6 days

What is Vitamin B12 (Hydroxocobalamin)?

Injectable form of B12 with longer retention vs. cyanocobalamin. Preferred for deficiency repletion and detoxification of cyanide.

How Vitamin B12 (Hydroxocobalamin) works

Converts to both active B12 coenzymes (methylcobalamin and adenosylcobalamin) after injection, and acts as a cyanide antidote by forming cyanocobalamin eliminating cyanide from tissues.

Benefits & uses

Energy/reduces fatigue
Red blood cell production
Nerve health
Cognitive support

Common uses: B12 deficiency, pernicious anemia, neuropathy, antidote for cyanide poisoning.

Cognitive

Vitamin B12 (Hydroxocobalamin) dosage

Typical dose: Deficiency: 1 mg SubQ/IM every week for 8 weeks, then monthly maintenance.

Vitamin B12 (Hydroxocobalamin) half-life

~2–6 days (plasma, longer than cyanocobalamin)

Vitamin B12 (Hydroxocobalamin) side effects

Injection site reactions. May cause temporary skin redness. Very safe overall.

Injection site pain or swelling
Temporary bright pink skin discoloration at injection site
Very rare: anaphylaxis (extremely uncommon)
Very well tolerated (water-soluble, low toxicity)

Commonly stacked with

Vitamin B9 (Folate)Vitamin B6 (P5P)

Track Vitamin B12 (Hydroxocobalamin) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.