VitaminWell-studiedVitamin

Vitamin B1 (Thiamine)

Also known as Vitamin B1

Half-life

~9–18 days

What is Vitamin B1 (Thiamine)?

Water-soluble B vitamin essential for carbohydrate metabolism and nerve function. Depleted by alcohol and refined carb diets.

How Vitamin B1 (Thiamine) works

Acts as a coenzyme (TPP) in pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase reactions — critical for converting glucose to ATP and supporting acetylcholine synthesis.

Benefits & uses

Energy metabolism
Nerve function
Corrects deficiency (common in heavy drinkers)

Common uses: Energy metabolism, nerve function, heart health, cognitive function, hangover recovery.

Cognitive

Vitamin B1 (Thiamine) dosage

Typical dose: General: 50–100 mg/day. Deficiency repletion: 100–300 mg/day. Benfotiamine form for neuropathy.

Vitamin B1 (Thiamine) half-life

~9–18 days (tissue stores)

Vitamin B1 (Thiamine) side effects

Very safe. High doses rarely cause GI upset. No known toxicity from oral doses.

Very rare: mild GI upset
Essentially non-toxic at supplemental doses
Intravenous high-dose may cause hypotension (uncommon)
Very well tolerated (water-soluble)

Track Vitamin B1 (Thiamine) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.