VitaminWell-studiedVitamin

Vitamin B3 (Niacin)

Also known as Vitamin B3

Half-life

~45 minutes

What is Vitamin B3 (Niacin)?

Water-soluble B vitamin involved in energy metabolism. High doses raise HDL and lower triglycerides.

How Vitamin B3 (Niacin) works

Precursor to NAD+ and NADP+ — essential cofactors in over 400 enzymatic reactions including glycolysis, TCA cycle, and fatty acid synthesis. At high doses, inhibits VLDL secretion to lower triglycerides.

Benefits & uses

Energy metabolism
Niacin can improve cholesterol profile
Skin health (niacinamide)

Common uses: Cholesterol management, energy metabolism, skin health (pellagra prevention).

Longevity

Vitamin B3 (Niacin) dosage

Typical dose: Flush form (nicotinic acid) 500–2000 mg/day for lipids. Extended-release reduces flushing. Start low and titrate.

Vitamin B3 (Niacin) half-life

~45 minutes (plasma)

Vitamin B3 (Niacin) side effects

Flushing (hot/red skin) common at doses >100 mg. May elevate blood glucose.

Flushing (prostaglandin-mediated — take aspirin 30 min before to reduce)
Elevated blood glucose (monitor if diabetic)
Hepatotoxicity with extended-release form at high doses
GI upset — always take with food
Niacin causes flushing (harmless)
Niacinamide is flush-free

Warnings & monitoring

High-dose niacin can affect liver/blood sugar — medical supervision for therapeutic doses

Track Vitamin B3 (Niacin) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.