VitaminWell-studiedVitamin

Vitamin B6 (P5P)

Also known as Vitamin B6

Half-life

~15–20 days

What is Vitamin B6 (P5P)?

Active form of B6, essential for neurotransmitter synthesis and hormone regulation. Used to manage prolactin on cycle.

How Vitamin B6 (P5P) works

As pyridoxal-5-phosphate (PLP), acts as coenzyme for >100 enzymatic reactions including transamination, decarboxylation, and synthesis of serotonin, dopamine, GABA, and norepinephrine. Modulates steroid hormone receptor activity.

Benefits & uses

Neurotransmitter/mood support
Protein metabolism
PMS symptom support
Works in ZMA

Common uses: Prolactin control, hormone regulation, amino acid metabolism, mood support.

Cognitive

Vitamin B6 (P5P) dosage

Typical dose: General: 25–50 mg/day. Prolactin management: 50–100 mg/day (B6). P5P form is preferred — better absorbed.

Vitamin B6 (P5P) half-life

~15–20 days (tissue-bound)

Vitamin B6 (P5P) side effects

Peripheral neuropathy at very high doses (>500 mg/day long-term). Stick to 50-100 mg.

Peripheral neuropathy with chronic high doses (>200–500 mg/day)
Sensory neuropathy most common side effect
P5P form safer than pyridoxine for long-term use
Well tolerated at normal doses

Warnings & monitoring

Very high chronic doses (>100 mg/day long-term) can cause nerve tingling

Track Vitamin B6 (P5P) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.