PeptideWell-studiedGrowth Hormone Secretagogue

Sermorelin

Typical dose

200–500 mcg

once daily (bedtime) · SubQ

Half-life

~10–20 minutes

What is Sermorelin?

Synthetic analogue of native GHRH (first 29 amino acids). FDA-approved for GH deficiency in children.

How Sermorelin works

Directly stimulates GHRH receptors on the pituitary somatotroph cells to produce a physiological GH pulse, maintaining natural pulsatile rhythm better than CJC-1295 with DAC.

Benefits & uses

GH stimulation
Anti-aging
Sleep improvement
Body composition
Recovery

Common uses: GH deficiency, anti-aging, body composition, sleep quality, long-term GH axis support.

Sermorelin dosage

Typical dose: Typical: 200–500 mcg per dose SubQ, once daily (usually bedtime). 12+ weeks.
Protocol notes: 200-500mcg per injection, daily before bed. Combine with Ipamorelin for synergistic effect.

Sermorelin half-life

~10–20 minutes (ultra-short, native GHRH analogue)

Sermorelin side effects

Injection site reactions, mild water retention. Very safe long-term.

Injection site redness or swelling
Mild water retention
Headaches (uncommon)
Flushing or tingling post-injection

Warnings & monitoring

Research use only
Fast before injection for optimal GH pulse
Avoid in active cancer

Preparation & storage

Preparation: Mix a 5 mg vial with 2 mL bac water → 2,500 mcg/mL. A 300 mcg dose = 0.12 mL = 12 units.
Reconstitution: Reconstitute a 5 mg vial with 2 mL BAC water → 2.5 mg/mL. A 300 mcg dose = 0.12 mL = 12 units on a U-100 syringe.
Storage: Lyophilized: refrigerate (2–8 °C). Reconstituted: refrigerate, stable 20 days.

Sermorelin interactions

with CJC-1295
Caution · mild
Both are GHRH analogs targeting the same receptor — combining provides no additive GH release and wastes peptide. Pick the longer-acting CJC-1295 for steady elevation.
Timing: Choose one GHRH analog; do not stack
with Ipamorelin
Compatible
A gentler alternative to CJC-1295/Ipamorelin; Sermorelin (native GHRH) combined with Ipamorelin produces physiological GH pulses suitable for long-term use.
Timing: Inject together before bed on an empty stomach

Commonly stacked with

Ipamorelin GHRP-2 BPC-157

Track Sermorelin in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.