Ipamorelin

What is Ipamorelin?

Pentapeptide GHRP with selective GH release without affecting cortisol or prolactin. Considered the cleanest GHRP for body composition and recovery.

How Ipamorelin works

Binds ghrelin receptors (GHS-R) in the pituitary, triggering GH pulses without hunger or cortisol spike.

Benefits & uses

• GH pulse stimulation
• Muscle retention
• Fat loss support
• Sleep quality
• Recovery
• Anti-aging

Common uses: GH release, body composition, recovery, anti-aging. Most selective GH secretagogue.

Ipamorelin dosage

Ipamorelin half-life

Ipamorelin side effects

Mild injection site reactions, lightheadedness initially.

Warnings & monitoring

• Research use only
• Fast 30+ minutes before injecting for optimal GH pulse
• Avoid in active cancer

Preparation & storage

Ipamorelin interactions

• with GHRP-6

  Caution · mild

  Both are ghrelin receptor agonists (GHRPs) — stacking them provides minimal additive GH release while compounding hunger, cortisol, and prolactin side effects.

  Timing: Do not combine in the same injection window; choose one GHRP per session

• with Insulin

  Caution · moderate

  GHRPs blunt insulin sensitivity acutely. If both are part of a protocol, separate by 90+ min and monitor glucose carefully.

  Timing: Do not co-administer in the same window

• with MK-677

  Caution · mild

  Both stimulate GH secretion through similar pathways (ghrelin receptor / GHRH). Stacking provides diminishing returns while compounding appetite stimulation, water retention, and potential cortisol elevation.

  Timing: Choose one GH secretagogue; do not use both daily long-term

• with BPC-157

  Compatible

  Complementary recovery stack: BPC-157 addresses local tissue healing and gut health while Ipamorelin promotes systemic GH release for recovery and sleep quality. No known adverse interaction.

  Timing: Administer separately; BPC-157 can be any time, Ipamorelin pre-bed fasted

• with CJC-1295

  Compatible

  The gold-standard GH peptide stack: CJC-1295 extends the GH pulse while Ipamorelin triggers selective GH release with minimal cortisol or prolactin elevation.

  Timing: Inject together 15–30 min before bed or post-workout on an empty stomach

• with DSIP

  Compatible

  DSIP (Delta Sleep-Inducing Peptide) improves sleep quality and reduces cortisol; Ipamorelin stimulates GH pre-sleep. The combination supports deep sleep and overnight recovery.

  Timing: Both taken pre-bed; complementary sleep quality and GH release effects

• with DSIP

  Compatible

  DSIP (Delta Sleep-Inducing Peptide) promotes deep sleep quality while Ipamorelin stimulates nighttime GH pulse. Combined, they support optimal recovery, sleep architecture, and growth hormone release.

  Timing: Both before bed; DSIP may be taken 30–60 min before sleep, Ipamorelin fasted

• with MK-677

  Compatible · low

  Complementary GH secretagogues. Ipamorelin is selective for GH release with minimal cortisol/prolactin; MK-677 provides sustained GH/IGF-1 elevation. Good recovery and body composition stack.

  Timing: Ipamorelin pre-bed fasted; MK-677 taken simultaneously for additive GH pulse

• with Sermorelin

  Compatible

  A gentler alternative to CJC-1295/Ipamorelin; Sermorelin (native GHRH) combined with Ipamorelin produces physiological GH pulses suitable for long-term use.

  Timing: Inject together before bed on an empty stomach

• with Tesamorelin

  Compatible

  Tesamorelin (FDA-approved GHRH analogue) and Ipamorelin work through GHRH and ghrelin receptor pathways respectively, providing GH amplification at different times of day.

  Timing: Tesamorelin in the morning for visceral fat; Ipamorelin before bed for recovery and sleep

• with Tesamorelin

  Compatible

  Tesamorelin's stabilized GHRH plus Ipamorelin's clean GHRP action is a low-side-effect alternative to CJC/Ipa.

  Timing: Same injection or back-to-back; nightly fasted

Commonly stacked with