BPC-157
Typical dose
250–750 mcg
1–2×/day · SubQ · often local to injury
Half-life
4 hours
What is BPC-157?
15-amino-acid peptide derived from a gastric protein. Widely used for healing and recovery of soft tissue, tendons, and gut lining.
How BPC-157 works
Promotes angiogenesis, upregulates growth factors, enhances nitric oxide synthesis at injury sites.
Benefits & uses
- Tendon/ligament healing
- Gut repair
- Wound healing
- Anti-inflammatory
- CNS regeneration
Common uses: Tendon/ligament healing, gut repair, wound healing, anti-inflammatory, CNS regeneration.
BPC-157 dosage
- Typical dose
- Typical: 250–500 mcg SubQ, 1–2×/day (often local to injury). 4–8 weeks.
- Protocol notes
- 250-500mcg daily, can be subcutaneous (systemic) or local injection
BPC-157 half-life
4 hours
BPC-157 side effects
Minimal — generally well tolerated.
- Minimal — generally well tolerated
- Mild injection site discomfort or redness
Warnings & monitoring
- Research use only
- Generally well tolerated
- Mild injection site discomfort or redness
Preparation & storage
- Preparation
- Mix a 5 mg vial with 2 mL bac water → 2,500 mcg/mL. A 500 mcg dose = 0.2 mL = 20 units.
- Reconstitution
- Reconstitute a 5 mg vial with 2 mL BAC water → 2.5 mg/mL. A 250 mcg dose = 0.1 mL = 10 units on a U-100 syringe.
- Storage
- Lyophilized powder: refrigerate (2–8 °C), away from light. Reconstituted: 2–8 °C, use within 30 days.
BPC-157 interactions
with NSAIDs
Caution · mildNSAIDs (ibuprofen, naproxen) inhibit prostaglandin synthesis, which may blunt BPC-157's healing mechanisms that partially rely on prostaglandin-mediated signaling. Temporary separation reduces this interaction.
Timing: Avoid taking NSAIDs within 2–4 hours of BPC-157 injection
with Epithalon
CompatibleEpithalon (a tetrapeptide) targets telomere elongation and pineal function; BPC-157 for tissue repair. No known adverse interaction — both are short peptides with excellent safety profiles.
Timing: Epithalon typically cycled 10–20 days; BPC-157 continuous or injury-specific
with GHK-Cu
CompatibleBoth peptides promote collagen synthesis and wound healing through non-overlapping mechanisms, making this a potent tissue-repair stack.
Timing: Administer at the same time or within the same injection window
with GHK-Cu
CompatibleComplementary healing peptides. BPC-157 promotes tissue repair and gut healing; GHK-Cu stimulates collagen synthesis and wound healing. Synergistic effects for recovery.
Timing: Can be administered together or separately; subcutaneous or intramuscular
with Ipamorelin
CompatibleComplementary recovery stack: BPC-157 addresses local tissue healing and gut health while Ipamorelin promotes systemic GH release for recovery and sleep quality. No known adverse interaction.
Timing: Administer separately; BPC-157 can be any time, Ipamorelin pre-bed fasted
with PT-141
CompatibleBPC-157 (healing/gut repair) and PT-141 (sexual function/MC4R agonist) act on entirely different receptor systems with no known pharmacological interaction.
Timing: Independent injection timing; no pharmacological conflict
with PT-141
CompatibleNo known interaction. PT-141 (Bremelanotide) activates melanocortin receptors for sexual arousal; BPC-157 for systemic healing and inflammation. Complementary use in optimization protocols.
Timing: Administer separately; PT-141 subcutaneous 1–2h before, BPC-157 as scheduled
with Retatrutide
CompatibleBPC-157's gut-healing properties counteract the nausea, gastroparesis, and gastritis often seen with high-dose Retatrutide titration.
Timing: BPC-157 daily to mitigate GLP-1 GI side effects
with Semaglutide
CompatibleBPC-157 helps with the gastric emptying delay and gut irritation common during semaglutide dose escalation.
Timing: BPC-157 250-500mcg daily during GLP-1 protocol
with Semax
CompatibleComplementary neuroprotective stack: BPC-157 supports gut-brain axis and nerve healing, while Semax elevates BDNF and cognitive function. No known pharmacological conflict.
Timing: SubQ BPC-157; Semax nasal — no timing conflict
with Semax
CompatibleNo known adverse interaction. BPC-157 supports gut and systemic healing; Semax promotes neurogenesis (BDNF) and cognitive function. Complementary neuro-protective and recovery stack.
Timing: BPC-157 subcutaneous daily; Semax intranasal morning
with TB-500
CompatibleBPC-157 and TB-500 work via complementary pathways (nitric oxide vs actin binding) for synergistic soft-tissue and tendon repair.
Timing: Can be injected simultaneously in separate sites or the same syringe
with TB-500
CompatibleThe classic healing combination. BPC-157 acts locally and systemically for tissue repair; TB-500 (Thymosin Beta-4) promotes cell migration and angiogenesis. Widely used for injury recovery.
Timing: Often combined as the 'healing stack'; administer daily or EOD
with Testosterone
CompatibleBPC-157 supports tendon, ligament, and gut health alongside testosterone protocols. Enhanced strength gains on testosterone increase injury risk — BPC-157 proactively supports connective tissue integrity.
Timing: BPC-157 SubQ/IM daily; no timing interaction with testosterone injection schedule
with Thymosin Alpha-1
CompatibleThymosin Alpha-1 modulates immune function while BPC-157 promotes tissue repair — complementary mechanisms for recovery, especially useful post-illness or post-surgery.
Timing: Can be co-administered SubQ; different injection sites recommended
with Tirzepatide
CompatibleDual-agonist GLP-1/GIP creates more pronounced GI stress than mono-agonists; BPC-157 supports the gastric mucosa under that load.
Timing: Concurrent — BPC-157 daily for the duration of GLP-1 use
Commonly stacked with
Track BPC-157 in Protokol.
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