VitaminEmergingVitamin

Vitamin K2 MK-7

Also known as Vitamin K2

Half-life

~72 hours

What is Vitamin K2 MK-7?

Long-chain menaquinone from natto (fermented soy). Superior bioavailability and long half-life vs MK-4.

How Vitamin K2 MK-7 works

Same mechanism as MK-4 (osteocalcin and MGP carboxylation) but 3-day half-life means once-daily dosing achieves sustained tissue levels. Natto-derived form has highest bioavailability.

Benefits & uses

Directs calcium to bone
May reduce arterial stiffness
Improves bone density with D3
Cardiovascular support

Common uses: Bone density, arterial health, cardiovascular protection, calcium metabolism.

Longevity

Vitamin K2 MK-7 dosage

Typical dose: 100–200 mcg/day once daily. Always combine with D3 for synergistic calcium regulation.

Vitamin K2 MK-7 half-life

~72 hours (long half-life — once daily dosing sufficient)

Vitamin K2 MK-7 side effects

Very safe. Warfarin interaction. More potent per mcg than MK-4 due to longer half-life.

Warfarin (Coumadin) interaction — contraindicated without physician supervision if on anticoagulants
Very safe at supplemental doses
Minor GI effects rarely reported
Well tolerated

Warnings & monitoring

Can interact with warfarin/anticoagulants — consult a doctor

Commonly stacked with

Vitamin D3

Track Vitamin K2 MK-7 in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.