VitaminEmergingVitamin

Vitamin K2 MK-4

Also known as Vitamin K2

Half-life

~1–2 hours

What is Vitamin K2 MK-4?

Short-chain menaquinone found in animal products. High doses shown to prevent bone fractures in Japanese research.

How Vitamin K2 MK-4 works

Activates osteocalcin to facilitate calcium deposition in bone matrix, and activates matrix Gla protein (MGP) to prevent calcification of arteries, kidneys, and soft tissues.

Benefits & uses

Directs calcium to bone
May reduce arterial stiffness
Improves bone density with D3
Cardiovascular support

Common uses: Bone density (osteocalcin activation), arterial health, cancer prevention in Japanese studies.

Longevity

Vitamin K2 MK-4 dosage

Typical dose: Bone health: 45 mg/day (Japanese pharmaceutical dose) in 3 divided doses. General: 1–15 mg/day.

Vitamin K2 MK-4 half-life

~1–2 hours (plasma — requires 3x/day dosing)

Vitamin K2 MK-4 side effects

Very safe. Short half-life requires multiple daily doses.

Warfarin interaction — do not supplement without physician oversight
Short half-life means split dosing is required for efficacy
Very safe profile even at high doses used in bone research
Well tolerated

Warnings & monitoring

Can interact with warfarin/anticoagulants — consult a doctor

Commonly stacked with

Vitamin D3

Track Vitamin K2 MK-4 in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.