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Vitamin D3+K2

Also known as Vitamin D3 K2

Half-life

D3: 15–25 days

What is Vitamin D3+K2?

Combined D3 and K2 MK-7. D3 improves calcium absorption; K2 directs calcium to bones rather than arteries.

How Vitamin D3+K2 works

D3 upregulates calcium absorption via VDR. K2 activates osteocalcin (directs calcium into bone) and matrix Gla protein (prevents arterial calcification), creating a synergistic bone-cardiovascular protection effect.

Benefits & uses

  • Bone density
  • Directs calcium correctly
  • Immune + cardiovascular support
  • Convenient pairing

Common uses: Bone health, cardiovascular protection, immune support, testosterone optimization.

Longevity

Vitamin D3+K2 dosage

Typical dose
5000 IU D3 + 100–200 mcg K2 MK-7 daily with fat-containing meal.

Vitamin D3+K2 half-life

D3: 15–25 days; K2 MK-7: ~72 hours

Vitamin D3+K2 side effects

Same as D3 alone. K2 is very safe at supplemental doses.

  • Rare hypercalcemia at excessive D3 doses
  • K2 may interact with warfarin (vitamin K antagonist) — consult physician
  • Very well tolerated at standard doses
  • Well tolerated

Track Vitamin D3+K2 in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.

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More Vitamin

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.