VitaminWell-studiedVitamin

Vitamin B3 (Niacinamide)

Also known as Vitamin B3

Half-life

~40–60 minutes

What is Vitamin B3 (Niacinamide)?

Non-flushing form of niacin. Supports NAD+ synthesis and DNA repair. Does NOT lower cholesterol like niacin.

How Vitamin B3 (Niacinamide) works

Converted to NAD+ via the salvage pathway, supporting sirtuin enzyme activity, PARP-mediated DNA repair, and mitochondrial function without the prostaglandin flush of niacin.

Benefits & uses

Energy metabolism
Niacin can improve cholesterol profile
Skin health (niacinamide)

Common uses: NAD+ precursor, DNA repair, skin health (topical), anxiety-reducing (GABA-modulating at high doses).

Longevity

Vitamin B3 (Niacinamide) dosage

Typical dose: NAD+ support: 300–1000 mg/day. Skin: topical 4–5% cream. Anti-aging: 500 mg twice daily.

Vitamin B3 (Niacinamide) half-life

~40–60 minutes (plasma)

Vitamin B3 (Niacinamide) side effects

Generally very safe. GI upset at doses >3 g/day. Mild nausea possible.

GI nausea at doses >2–3 g/day
Does not cause flushing (advantage over niacin)
Mild glucose effects at very high doses — rare
Niacin causes flushing (harmless)
Niacinamide is flush-free

Warnings & monitoring

High-dose niacin can affect liver/blood sugar — medical supervision for therapeutic doses

Track Vitamin B3 (Niacinamide) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.