Pregnenolone

What is Pregnenolone?

A precursor hormone ('mother hormone') from which other steroid hormones are made, used for cognition, mood, and hormonal support.

How Pregnenolone works

An upstream steroid precursor to DHEA, progesterone, and other hormones; may act as a neurosteroid affecting memory and mood.

Benefits & uses

• May support memory/cognition
• Mood/stress support
• Upstream hormonal precursor

Common uses: Cognitive support, mood, hormonal/adrenal support.

Pregnenolone dosage

Pregnenolone side effects

Warnings & monitoring

• It IS a hormone precursor — can influence downstream sex/stress hormones; caution with hormone-sensitive conditions

Pregnenolone interactions

• with DHEA

  Compatible

  Pregnenolone is the master steroid precursor; DHEA is downstream. Together they support neurosteroid pathways and adrenal function. Often used to mitigate 'tren rage' or cognitive sides.

  Timing: Both taken in morning; may reduce neurological side effects of testosterone/trenbolone

• with Testosterone

  Compatible

  Pregnenolone supplementation during TRT may counteract neurological side effects and support mood, cognitive function, and libido through neurosteroid mechanisms.

  Timing: Pregnenolone taken in the morning at 50–100mg