DHEA

What is DHEA?

Adrenal precursor hormone. Converts to testosterone and estrogen. Helps with age-related hormonal decline.

How DHEA works

A precursor hormone converted to sex hormones (testosterone/estrogen); levels decline with age, which is the rationale for supplementing.

Benefits & uses

• Supports declining hormone levels with age
• May support libido/mood/bone
• Precursor to testosterone & estrogen

Common uses: Hormone support in older adults, adrenal support, libido, wellbeing, bone density.

DHEA dosage

DHEA side effects

Acne, oily skin, hair loss, hormone-sensitive tumor risk.

Warnings & monitoring

• It IS a hormone — converts to testosterone/estrogen; caution with hormone-sensitive conditions/cancers; banned by NCAA; not a benign supplement

DHEA interactions

• with Testosterone

  Caution · mild

  DHEA is a precursor to both testosterone and estrogen. Adding exogenous DHEA alongside testosterone can unpredictably shift the androgen/estrogen balance — particularly estrogen-elevating in women and older men.

  Timing: Low-dose DHEA (10–25 mg) may be acceptable alongside TRT; avoid higher doses

• with Pregnenolone

  Compatible

  Pregnenolone is the master steroid precursor; DHEA is downstream. Together they support neurosteroid pathways and adrenal function. Often used to mitigate 'tren rage' or cognitive sides.

  Timing: Both taken in morning; may reduce neurological side effects of testosterone/trenbolone

• with Testosterone

  Compatible

  DHEA is an androgen precursor that can convert to testosterone and estradiol. Supplementing on TRT is generally redundant but may support adrenal function and libido for some users.

  Timing: DHEA typically taken in the morning to mirror natural cortisol rhythm