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Phosphatidylserine

Half-life

~3-4 days

What is Phosphatidylserine?

Phospholipid that comprises 15% of brain cell membranes. Reduces cortisol and stress.

How Phosphatidylserine works

Binds to glucocorticoid receptors and modulates corticotropin-releasing hormone (CRH) to reduce stress response. Also supports neuronal membrane plasticity.

Benefits & uses

  • Memory & cognition
  • May lower cortisol
  • Supports focus
  • Age-related cognitive support

Common uses: Memory, stress/cortisol, focus, cognitive aging.

CognitiveRecovery

Phosphatidylserine dosage

Typical dose
100–300 mg daily

Phosphatidylserine half-life

~3-4 days (tissue incorporation)

Phosphatidylserine side effects

  • Minimal side effects
  • Very safe long-term
  • May take 4-8 weeks for cortisol-lowering effects
  • Generally well tolerated
  • Insomnia at high evening doses

Track Phosphatidylserine in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.