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Agmatine Sulfate

Also known as Agmatine

Half-life

~2 hours

What is Agmatine Sulfate?

Decarboxylated arginine metabolite. Modulates nitric oxide, neurotransmission, and insulin sensitivity.

How Agmatine Sulfate works

Inhibits nitric oxide synthase (regulating rather than simply increasing NO), acts as agonist at imidazoline receptors to enhance insulin secretion, and modulates NMDA receptors producing analgesic and neuroprotective effects.

Benefits & uses

Common uses: Nitric oxide support, muscle pumps, cognitive enhancement, pain management, insulin sensitization.

MuscleRecovery

Agmatine Sulfate dosage

Typical dose
500 mg–2 g/day. Pre-workout: 1 g 30 min before training. Separate from arginine supplementation.
Reference range
Observational: ~500–1000 mg (pre-workout for pumps)Clinical or reference range, not a personal recommendation.

Agmatine Sulfate half-life

~2 hours (plasma)

Agmatine Sulfate side effects

Generally safe at standard doses. GI upset possible. Nausea at high doses.

  • GI upset and nausea at high doses
  • Do not combine with MAOI medications
  • Interacts with arginine — take separately
  • Generally well tolerated
  • Mild GI upset

Track Agmatine Sulfate in Protokol.

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More Nootropic

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.