PeptideGLP-1GLP-1 Agonist
Mazdutide
Dual agonist (GLP-1 / glucagon)
Typical dose
1.5–9 mg weekly
once weekly · SubQ · titrate up
Half-life
~weekly dosing
What is Mazdutide?
GLP-1/glucagon dual agonist; emerging weight-loss and metabolic peptide.
How Mazdutide works
Dual GLP-1/glucagon agonist (oxyntomodulin-based) — GLP-1 curbs appetite/slows stomach while glucagon raises energy expenditure.
Benefits & uses
- Weight loss
- Appetite reduction
- Glucagon-driven energy expenditure
- Blood-sugar improvement
- Potential fatty-liver benefit
Common uses: Fat loss / obesity, metabolic health, fatty liver.
Mazdutide dosage
- Typical dose
- Typical: start ~1.5–3 mg/week SubQ, titrate up toward ~6–9 mg/week. Once weekly.
Mazdutide half-life
~weekly dosing
Mazdutide side effects
- Diarrhea
- Nausea
- Upper respiratory infection
- Vomiting
- Heart-rate increase (tended higher than placebo)
Warnings & monitoring
- Titrate slowly for GI tolerance
- Glucagon component can raise heart rate — monitor
- Class GLP-1 risks (pancreatitis/gallbladder) apply
- Thyroid C-cell class caution
- Not for pregnancy
Preparation & storage
- Preparation
- Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. A 3 mg dose = 0.6 mL = 60 units. Start ~1.5–3 mg/week.
- Reconstitution
- Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL. A 3 mg dose = 0.6 mL = 60 units on a U-100 syringe.
More GLP-1 Agonist
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- LiraglutideOlder daily GLP-1 agonist (shorter half-life than weekly agents).
- Reta+Cagri BlendFixed blend of retatrutide and cagrilintide.
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