ProtokolPROTOKOL
PeptideGLP-1GLP-1 Agonist

Mazdutide

Dual agonist (GLP-1 / glucagon)

Typical dose

1.5–9 mg weekly

once weekly · SubQ · titrate up

Half-life

~weekly dosing

What is Mazdutide?

GLP-1/glucagon dual agonist; emerging weight-loss and metabolic peptide.

How Mazdutide works

Dual GLP-1/glucagon agonist (oxyntomodulin-based) — GLP-1 curbs appetite/slows stomach while glucagon raises energy expenditure.

Benefits & uses

  • Weight loss
  • Appetite reduction
  • Glucagon-driven energy expenditure
  • Blood-sugar improvement
  • Potential fatty-liver benefit

Common uses: Fat loss / obesity, metabolic health, fatty liver.

Mazdutide dosage

Typical dose
Typical: start ~1.5–3 mg/week SubQ, titrate up toward ~6–9 mg/week. Once weekly.

Mazdutide half-life

~weekly dosing

Mazdutide side effects

  • Diarrhea
  • Nausea
  • Upper respiratory infection
  • Vomiting
  • Heart-rate increase (tended higher than placebo)

Warnings & monitoring

  • Titrate slowly for GI tolerance
  • Glucagon component can raise heart rate — monitor
  • Class GLP-1 risks (pancreatitis/gallbladder) apply
  • Thyroid C-cell class caution
  • Not for pregnancy

Preparation & storage

Preparation
Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. A 3 mg dose = 0.6 mL = 60 units. Start ~1.5–3 mg/week.
Reconstitution
Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL. A 3 mg dose = 0.6 mL = 60 units on a U-100 syringe.

Track Mazdutide in Protokol.

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More GLP-1 Agonist

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.