PeptideGLP-1Well-studiedGLP-1 Agonist

GLP-1 (Native)

Native incretin hormone — not a modified analog

Also known as GLP-1 Native, Native GLP-1, GLP-1 7-36, Glucagon-Like Peptide-1

Typical dose

Reference entry — not self-administered

parent hormone of the GLP-1 class

Half-life

~1–2 minutes

What is GLP-1 (Native)?

Native glucagon-like peptide-1 — the body's own incretin hormone that the modern GLP-1 drugs (semaglutide etc.) are analogs of. Very short-acting on its own (degraded by DPP-4 in minutes), so rarely run directly vs the long-acting analogs.

How GLP-1 (Native) works

Incretin hormone — stimulates glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite. Degraded by DPP-4 within minutes, which is why analogs (resistant to DPP-4) are used instead.

Benefits & uses

The reference incretin
Glucose-dependent insulin (low hypoglycemia risk)
Appetite/satiety

Common uses: Reference/educational; the parent hormone of the GLP-1 drug class.

Fat Loss

GLP-1 (Native) dosage

Typical dose: Native GLP-1 is not practically self-administered (minutes-long half-life) — the long-acting analogs (semaglutide/tirzepatide/etc.) are used instead. Research/reference entry.

GLP-1 (Native) half-life

~1–2 minutes (DPP-4 degradation)

GLP-1 (Native) side effects

Nausea (class effect)
Not practical to run directly

Warnings & monitoring

Reference entry — the analogs (semaglutide etc.) are what's actually run; native GLP-1's minutes-long half-life makes direct use impractical

Preparation & storage

Reconstitution: Reconstitute with BAC water per product labelling; dose by volume.

Track GLP-1 (Native) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.