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PeptideGLP-1GLP-1 Agonist

CagriSema (Cagrilintide + Semaglutide)

Combination (amylin analog + GLP-1: cagrilintide + semaglutide)

Typical dose

titrate to ~2.4 mg each weekly

once weekly · SubQ · blend

Half-life

~weekly

What is CagriSema (Cagrilintide + Semaglutide)?

Fixed blend of cagrilintide (amylin) and semaglutide (GLP-1).

How CagriSema (Cagrilintide + Semaglutide) works

Combines cagrilintide (amylin analog) with semaglutide (GLP-1) — layers amylin satiety on top of GLP-1 appetite suppression for additive effect.

Benefits & uses

  • Greater weight loss than either component alone (~20% at 68 wks)
  • Dual appetite pathways (amylin + GLP-1)
  • Blood-sugar improvement

Common uses: Significant fat loss / obesity, type 2 diabetes.

Blend composition

Mix the 10 mg blend (5 mg + 5 mg) with 2 mL bac water → 2.5 mg each per mL.

CagriSema (Cagrilintide + Semaglutide) dosage

Typical dose
Blend, dosed by volume — titrate both components together up toward 2.4 mg each/week. Once weekly.

CagriSema (Cagrilintide + Semaglutide) half-life

~weekly

CagriSema (Cagrilintide + Semaglutide) side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Injection-site reactions (GI events are the most common, consistent with both drug classes)

Warnings & monitoring

  • Titrate slowly — combined GI burden of two appetite drugs
  • Class GLP-1 risks: pancreatitis, gallbladder, gastroparesis
  • Thyroid C-cell class caution (semaglutide component)
  • Not for pregnancy

Preparation & storage

Reconstitution
Reconstitute the blend vial (e.g. 10 mg total, 5+5) with 2 mL BAC water and dose by VOLUME to hit the target of each component. Do not compute a single per-unit figure.

Track CagriSema (Cagrilintide + Semaglutide) in Protokol.

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More GLP-1 Agonist

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.