PeptideGLP-1GLP-1 Agonist
Liraglutide
GLP-1 agonist
Typical dose
0.6–3.0 mg DAILY
once DAILY (not weekly) · SubQ
Half-life
~13 hours
What is Liraglutide?
Older daily GLP-1 agonist (shorter half-life than weekly agents).
How Liraglutide works
GLP-1 receptor agonist — reduces appetite, slows gastric emptying, and stimulates glucose-dependent insulin release. Daily injection (shorter-acting than weekly agents).
Benefits & uses
- Weight loss
- Appetite reduction
- Blood-sugar control
- Cardiovascular benefit (established in T2DM)
Common uses: Fat loss / obesity, type 2 diabetes.
Liraglutide dosage
- Typical dose
- Typical: start 0.6 mg/day SubQ, titrate weekly (0.6→1.2→1.8→2.4→3.0 mg/day). Once DAILY, not weekly.
Liraglutide half-life
~13 hours (daily dosing)
Liraglutide side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Headache
- Injection-site reactions
Warnings & monitoring
- Daily dosing; titrate slowly
- Class risks: pancreatitis, gallbladder disease
- Boxed warning: medullary thyroid carcinoma / MEN2 — contraindicated with that history
- Not for pregnancy
Preparation & storage
- Preparation
- Usually pre-filled. If mixing a 5 mg vial with 1 mL bac water → 5 mg/mL, a 0.6 mg dose = 0.12 mL = 12 units. Titrate weekly.
- Reconstitution
- Usually supplied pre-filled. If lyophilized: reconstitute a 5 mg vial with 1 mL BAC water → 5 mg/mL. A 0.6 mg dose = 0.12 mL = 12 units on a U-100 syringe.
More GLP-1 Agonist
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- MazdutideGLP-1/glucagon dual agonist; emerging weight-loss and metabolic peptide.
- Reta+Cagri BlendFixed blend of retatrutide and cagrilintide.
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