Tesofensine
Also known as NS2330, weight loss, appetite suppressant
Half-life
~8 days
What is Tesofensine?
Triple monoamine reuptake inhibitor (NE/DA/5-HT). Originally developed for Parkinson's and Alzheimer's. Potent appetite suppression and metabolic rate increase. Phase 2 trials showed ~10% body weight loss at 0.5mg/day. Not FDA approved for obesity but used off-label.
How Tesofensine works
Inhibits reuptake of norepinephrine, dopamine and serotonin in the CNS, producing sustained appetite suppression and increased basal metabolic rate.
Benefits & uses
- Appetite suppression
- Weight loss
- Metabolic rate increase
- Fat loss
Common uses: Weight loss, appetite suppression, metabolic rate increase, fat loss.
Tesofensine dosage
Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.
- Typical dose
- 0.25-0.5mg daily oral
- Protocol notes
- Start 0.25mg daily for 2 weeks, increase to 0.5mg if tolerated. Take with or without food.
Tesofensine half-life
~8 days
Tesofensine side effects
- Increased heart rate
- Blood pressure elevation
- Insomnia
- Dry mouth
- Nausea
- Constipation
Warnings & monitoring
- Research use only — not FDA approved
- Raises heart rate and blood pressure
- Do not combine with MAOIs
- Monitor cardiovascular parameters
- Insomnia common — take morning only
- Abuse potential — dopaminergic mechanism
Tesofensine interactions
with Semaglutide
Caution · moderateTesofensine raises BP/HR via NE/DA reuptake inhibition; combined with GLP-1 anorexia, can drive excessive lean mass loss and cardiovascular strain.
Timing: Do not initiate simultaneously; separate by 4+ weeks if cycling
Commonly stacked with
Track Tesofensine in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
