5-Amino-1MQ
NNMT inhibitor (small molecule, not a peptide)
Typical dose
50–150 mg oral · 150–500 mcg SubQ
dual route — note the mg/mcg difference
Half-life
~3
What is 5-Amino-1MQ?
An NNMT (nicotinamide N-methyltransferase) inhibitor — a small molecule, not a peptide — studied for fat metabolism, lean-mass preservation, and cellular energy. Run as oral capsules OR reconstituted for SubQ injection.
How 5-Amino-1MQ works
Inhibits NNMT, preserving nicotinamide for NAD+ production and activating SIRT1 pathways tied to metabolic efficiency and fat-cell shrinkage.
Benefits & uses
- Fat metabolism / fat-cell shrinkage
- Raises NAD+
- Lean-mass preservation
- Cellular energy
- Fat loss
- NAD+ optimization
- Metabolic enhancement
- Anti-obesity
Common uses: Fat loss, metabolic/NAD+ support, body composition.
5-Amino-1MQ dosage
- Typical dose
- ORAL: 50–150 mg/day, oral capsule, 8–12 weeks. SUBQ: 150–500 mcg/day SubQ (start 150 mcg week 1, standard 300 mcg AM pre-meal, advanced 500 mcg split AM/PM).
- Protocol notes
- 50-100mg per day oral.
5-Amino-1MQ half-life
~3.8–6.9 hrs (supports twice-daily)
5-Amino-1MQ side effects
- Generally well tolerated in reports
- Limited human data
- Research use only
- Limited human data available
Warnings & monitoring
- Research use only
- Limited human data available
- 🔴 HONEST NOTE (credibility): sources genuinely split on SubQ dosing — the mcg-level protocols (150–500 mcg) are practical SubQ; the higher mg totals (50–150 mg) require impractical injection volumes (50 mg = 10 mL, far over the 2–5 mL/site limit), which is WHY oral is often preferred at those doses. Human data is limited/extrapolated.
- Not FDA approved / research use
Preparation & storage
- Preparation
- Oral — no mixing needed. Taken as a capsule.
- Reconstitution
- Dual route. Oral capsules need no reconstitution. For SubQ: 10 mg vial + 1–2 mL BAC water → 5 mg/mL. Swirl (don't shake). Refrigerate, use within ~30 days.
5-Amino-1MQ interactions
with NAD+
Compatible5-Amino-1MQ blocks NNMT (which depletes NAD+ precursors) — stacking with exogenous NAD+ amplifies NAD+ availability for sirtuin and CD38 pathways.
Timing: NAD+ injections weekly, 5-Amino-1MQ daily oral
with Semaglutide
Compatible5-Amino-1MQ activates AMPK and shifts NAD+ flux toward lipolysis — complementary to GLP-1 driven appetite suppression.
Timing: Stack daily during fat-loss phase
Commonly stacked with
Track 5-Amino-1MQ in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
