MOTS-c
Typical dose
5–10 mg
2–3×/week · SubQ
Half-life
~1-2 hours
What is MOTS-c?
Mitochondrial-derived peptide linked to metabolic flexibility, insulin sensitivity, and exercise-mimetic effects.
How MOTS-c works
Activates AMPK-related pathways to improve glucose utilization and cellular energy handling.
Benefits & uses
Common uses: Metabolic health, glucose control, endurance and body composition support.
MOTS-c dosage
- Typical dose
- Typical: 5–10 mg, 2–3×/week SubQ. 4–8 weeks.
MOTS-c half-life
~1-2 hours
MOTS-c side effects
Generally mild; transient fatigue or injection site discomfort.
- Mild fatigue
- Injection site discomfort
Preparation & storage
- Preparation
- Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. A 5 mg dose = 1 mL = 100 units.
- Reconstitution
- Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL. A 5 mg dose = 1 mL = 100 units on a U-100 syringe.
- Storage
- Refrigerate after reconstitution (2–8 °C).
MOTS-c interactions
with NAD+
CompatibleMOTS-c is a mitochondrial-derived peptide that activates AMPK and improves metabolic flexibility. Combined with NAD+ (sirtuin activator), this stack comprehensively supports mitochondrial biogenesis and cellular energy.
Timing: MOTS-c SubQ daily; NAD+ separately — complementary mitochondrial support
with SS-31
CompatibleMOTS-c boosts mitochondrial biogenesis while SS-31 (Elamipretide) protects the inner mitochondrial membrane — complementary pathways for cellular energy.
Timing: Stack daily; MOTS-c morning, SS-31 evening or split dosing
Commonly stacked with
Track MOTS-c in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
