Selank
Typical dose
250–500 mcg
1–2×/day · nasal or SubQ
Half-life
~15–60 minutes
What is Selank?
Russian anxiolytic peptide derived from tuftsin. Modulates GABA and BDNF.
How Selank works
Modulates GABA-A receptors and increases BDNF expression while inhibiting enkephalin-degrading enzymes, producing anxiolytic effects without sedation or dependence.
Benefits & uses
- Anxiolytic
- Cognitive enhancement
- Immune modulation
- Mood stabilization
- Memory improvement
Common uses: Anxiety, stress, cognition, depression, BDNF stimulation.
Selank dosage
- Typical dose
- Typical: 250–500 mcg/day (nasal) or SubQ, 1–2×/day. 2–4 weeks.
- Protocol notes
- 250-3000mcg intranasally per day. SubQ: 250-500mcg per injection.
- Reference range
- Observational; intranasal dosing per productClinical or reference range, not a personal recommendation.
Selank half-life
~15–60 minutes (nasal absorption)
Selank side effects
Very safe. Mild fatigue possible.
- Mild fatigue (uncommon, typically dose-dependent)
- Very rare: mild nasal irritation from repeated intranasal use
- No dependence or withdrawal reported
- Generally well tolerated
- Nasal irritation
Warnings & monitoring
- Research use only
- Gray-market/limited Western clinical data.
Preparation & storage
- Preparation
- Often a nasal spray. If SubQ: mix 5 mg with 2 mL bac water → 2,500 mcg/mL; a 300 mcg dose = 0.12 mL = 12 units.
- Reconstitution
- Commonly used as a nasal spray. If SubQ: reconstitute a 5 mg vial with 2 mL BAC water → 2.5 mg/mL; a 300 mcg dose = 0.12 mL = 12 units.
- Storage
- Refrigerate (2–8 °C). Nasal solution: use within 30 days of opening. Protect from light.
Selank interactions
with DSIP
CompatibleDSIP for sleep architecture, Selank for daytime anxiolysis — non-overlapping windows, no receptor competition.
Timing: DSIP pre-sleep, Selank daytime
with Semax
CompatibleComplementary nootropic peptides. Selank has anxiolytic and immune-modulating effects; Semax stimulates BDNF and cognitive performance. Often combined for anxiety + focus without sedation.
Timing: Both administered intranasally; Selank for anxiety, Semax for cognition/energy
with Semax
CompatibleSelank (anxiolytic/GABA-modulatory) and Semax (BDNF/nootropic) have distinct mechanisms and combine for a calm, focused cognitive state without sedation.
Timing: Administer both nasally in the morning; may alternate days if budget-conscious
with Semax
CompatibleSelank's anxiolytic profile complements Semax's nootropic/dopaminergic action — a classic anxious-overachiever stack with well-documented synergy.
Timing: Often dosed together intranasally morning and afternoon
Commonly stacked with
Track Selank in Protokol.
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More Nootropic
- Adamax 1032Research nootropic peptide; limited data.
- DihexaOrally active angiotensin-derived experimental nootropic peptide mimetic.
- N-Acetyl Selank AmidateStabilized (acetylated/amidated) Selank variant; anxiolytic/nootropic.
- N-Acetyl Semax AmidateStabilized (acetylated/amidated) Semax variant; nootropic/neuroprotective.
- PE-22-28Spadin analog investigated for mood/neuroplasticity.
- PinealonShort neuropeptide studied for cognitive and pineal-axis effects.