PeptideAnecdotalNootropic

PE-22-28

Experimental peptide (spadin analog)

Typical dose

250–500 mcg

once daily · SubQ or nasal

Half-life

short

What is PE-22-28?

Spadin analog investigated for mood/neuroplasticity.

How PE-22-28 works

A spadin-derived peptide that blocks the TREK-1 potassium channel — a mechanism studied for rapid antidepressant effects and neurogenesis in animal models.

Benefits & uses

Antidepressant interest (fast-acting in animal models)
Neuroplasticity/neurogenesis interest
Mood support (research)

Common uses: Mood/depression research, neuroplasticity (experimental).

PE-22-28 dosage

Typical dose: Typical: ~250–500 mcg SubQ or intranasal (research, mood/neuro). Short courses.

PE-22-28 half-life

short

PE-22-28 side effects

Limited human data
Unknown human side-effect profile

Warnings & monitoring

🔴 Research chemical — essentially NO human safety data. Affects brain ion channels/mood. Not for use as a mental-health treatment; see a doctor for depression. Experimental only.

Preparation & storage

Preparation: Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. A 250 mcg dose = 0.05 mL = 5 units.
Reconstitution: Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL. A 250 mcg dose = 0.05 mL = 5 units on a U-100 syringe.

Track PE-22-28 in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.