Clomiphene (Clomid)
SERM
Also known as Clomid, clomiphene, clomi
Half-life
~5–7 days
What is Clomiphene (Clomid)?
SERM that stimulates LH and FSH production. Standard PCT component alongside Nolvadex.
How Clomiphene (Clomid) works
Competitively binds hypothalamic estrogen receptors, reducing negative feedback and triggering increased GnRH pulsatility, which drives LH and FSH release from the pituitary.
Benefits & uses
Common uses: PCT, HPG axis stimulation, testosterone recovery, male fertility.
Clomiphene (Clomid) dosage
Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.
- Reference range
- Literature reports ~25–50 mg daily in PCT (often tapered); individualClinical or reference range, not a personal recommendation.
Clomiphene (Clomid) half-life
~5–7 days (zuclomiphene isomer can accumulate up to 30 days)
Clomiphene (Clomid) side effects
Mood swings, emotional blunting, vision disturbances, headaches.
- Mood swings and emotional blunting (zuclomiphene isomer)
- Visual disturbances (floaters, visual trails)
- Headaches
- Hot flashes
- Emotional lability — enclomiphene preferred by some for fewer mood effects
- Mood swings/irritability
- Vision disturbances
Warnings & monitoring
- Prescription medication — requires a doctor + bloodwork. Vision changes warrant stopping.
Monitoring: Hormone panel (LH/FSH/T/E2); watch mood/vision (zuclomiphene isomer).
Preparation & storage
- Storage
- Room temperature (15–30 °C). Protect from moisture and light.
Clomiphene (Clomid) interactions
with HCG
Caution · mildHCG should precede Clomid in PCT to prime the testes, but concurrent long-term use can desensitize LH receptors and blunt the SERM effect.
Timing: Run HCG first for 2–3 weeks before adding Clomid; do not use long-term together
with Nolvadex
Caution · mildCombining SERMs in PCT is effective for HPG axis recovery but increases the risk of visual disturbances, mood changes, and estrogen rebound — monitor closely.
Timing: Stagger doses: Clomid in AM, Nolvadex in PM; use lower doses of each
with Aromasin
CompatibleAromasin during PCT controls estrogen rebound while Clomid stimulates LH/FSH production. Unlike Anastrozole, Aromasin does not interfere with Clomid's pituitary activity — a standard PCT combination.
Timing: Standard PCT protocol; can run concurrently
with HCG
Compatible · lowHCG maintains testicular sensitivity during suppression; Clomid then restores pituitary LH/FSH drive. Sequential use is more effective than concurrent — HCG desensitizes LH receptors if continued during PCT.
Timing: Run HCG during cycle/cruise, stop 4–5 days before starting Clomid PCT
with HCG
CompatibleHCG mimics LH, preserving Leydig cell function during suppression. Clomid then restarts endogenous LH/FSH post-cycle.
Timing: HCG during cycle to maintain testicular volume; Clomid in PCT
with Nolvadex
CompatibleClassic dual-SERM PCT. Mechanisms complement: Clomid drives gonadotropin recovery, Nolva blocks estrogen rebound.
Timing: PCT protocol — Clomid 50/50/25/25 + Nolva 20/20/10/10 over 4 weeks
with Nolvadex
Compatible · lowSERM combination for PCT. Nolvadex (tamoxifen) blocks estrogen at pituitary/breast; Clomid (clomiphene) stimulates LH/FSH production. Standard PCT combo for recovery of HPTA.
Timing: Combine in PCT starting 2 weeks after last long-ester injection
Commonly stacked with
Track Clomiphene (Clomid) in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
