Exemestane (Aromasin)
Aromatase Inhibitor
Also known as Aromasin, aromasin, exemestane
Half-life
~24 hours
What is Exemestane (Aromasin)?
Steroidal (suicidal) AI. Permanently deactivates aromatase enzyme. No estrogen rebound.
How Exemestane (Aromasin) works
Steroidal suicide aromatase inhibitor irreversibly inactivating CYP19 enzyme.
Benefits & uses
Common uses: Estrogen control, PCT AI of choice (no rebound), on-cycle use.
Exemestane (Aromasin) dosage
Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.
- Reference range
- Literature reports ~10–25 mg (daily to a few times weekly), highly individual, titrated to bloodworkClinical or reference range, not a personal recommendation.
Exemestane (Aromasin) half-life
~24 hours
Exemestane (Aromasin) side effects
Joint pain, libido loss if overdone. Better lipid profile than anastrozole.
- Low-estrogen fatigue/libido issues
- Joint stiffness
- Bone-density risk long-term
- Joint pain
- Fatigue
- Low libido/mood if E2 crashed
Warnings & monitoring
- Prescription medication — requires a doctor and estradiol monitoring. Don't self-dose without bloodwork.
Monitoring: Requires estradiol bloodwork; same crash risk as other AIs.
Exemestane (Aromasin) interactions
with Arimidex
Caution · moderateBoth suppress aromatase; stacking risks E2 crash (joint pain, low libido, depression). Cycle one or the other based on E2 bloodwork.
Timing: Choose one AI per cycle
with Clomid
CompatibleAromasin during PCT controls estrogen rebound while Clomid stimulates LH/FSH production. Unlike Anastrozole, Aromasin does not interfere with Clomid's pituitary activity — a standard PCT combination.
Timing: Standard PCT protocol; can run concurrently
with Nolvadex
CompatibleExemestane (Aromasin, a suicidal AI) and Nolvadex can be safely combined. Unlike Anastrozole, Aromasin does not significantly antagonize Nolvadex's mechanism — this combination is used in some PCT protocols.
Timing: Aromasin with food; Nolvadex any time — can be taken same day
with Testosterone
Compatible · lowExemestane (Aromasin) is a suicidal AI used with testosterone to manage aromatization. Steroidal AI with possible anabolic properties. Monitor E2 closely.
Timing: Take exemestane EOD or per bloodwork-guided protocol
with Testosterone
CompatibleExemestane (suicidal AI) permanently binds aromatase — effective estrogen control for testosterone cycles. Preferred by many over Anastrozole as it doesn't risk rebound aromatization and is PCT-compatible.
Timing: Aromasin 12.5–25 mg every other day with food; adjust to bloodwork
Commonly stacked with
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