ProtokolPROTOKOL
Medication

Pregabalin

Half-life

~6

What is Pregabalin?

Alpha2-delta calcium-channel ligand for neuropathic pain/anxiety modulation.

How Pregabalin works

Binds alpha2-delta subunit of voltage-gated calcium channels reducing excitatory neurotransmitter release.

Pregabalin half-life

~6.3 hours

Pregabalin side effects

  • Dizziness/somnolence
  • Weight gain/edema
  • Dependence potential

Pregabalin interactions

  • with Phenibut

    Avoid · severe

    Phenibut (GABA-B) plus pregabalin (alpha-2-delta) compounds sedation and dependence risk. Tolerance and withdrawal interactions are severe.

    Timing: Do not combine — both GABA-active

Track Pregabalin in Protokol.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.