Phenibut
Half-life
~5-6 hours
What is Phenibut?
GABA-B agonist with strong anxiolytic effects. Very addictive — must be cycled carefully.
How Phenibut works
GABA-B receptor agonism with mild alpha2-delta effects reduces anxiety but carries rapid tolerance and dependence potential.
Benefits & uses
Common uses: Anxiety, social anxiety, sleep, mild euphoria, withdrawal from alcohol.
Phenibut dosage
- Reference range
- Observational; strongly cautioned against regular useClinical or reference range, not a personal recommendation.
Phenibut half-life
~5-6 hours
Phenibut side effects
HIGH ADDICTION POTENTIAL. Rebound anxiety, dependence, severe withdrawal. Max 2x/week.
- Severe tolerance/dependence
- Rebound anxiety/insomnia
- Sedation and motor impairment
- 🔴 Rapid tolerance + physical dependence
- 🔴 Severe withdrawal (rebound anxiety, insomnia, agitation)
- Sedation
- Next-day grogginess
Warnings & monitoring
- 🔴 High dependence/withdrawal risk — do NOT use regularly. Withdrawal can be severe and require medical help. Additive with alcohol/sedatives (dangerous). Not a benign nootropic.
Phenibut interactions
with Alcohol
Avoid · severePhenibut's GABA-B agonism plus alcohol's CNS depression risks respiratory depression and blackouts. Dependence develops rapidly.
Timing: Never combine
with Pregabalin
Avoid · severePhenibut (GABA-B) plus pregabalin (alpha-2-delta) compounds sedation and dependence risk. Tolerance and withdrawal interactions are severe.
Timing: Do not combine — both GABA-active
Track Phenibut in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
