Pramipexole (Mirapex)
Dopamine Agonist
Also known as Mirapex, prami, pramipexole
Half-life
~8-12 hours
What is Pramipexole (Mirapex)?
Dopamine agonist used at low doses to lower prolactin. Shorter-acting alternative to cabergoline, taken at night because sedation and nausea are the dose-limiting effects.
How Pramipexole (Mirapex) works
Selective D2/D3 dopamine receptor agonist; dopaminergic tone at the pituitary suppresses prolactin secretion from lactotroph cells.
Benefits & uses
Common uses: Prolactin control on 19-nor compounds, prolactin-induced gyno, libido restoration.
Pramipexole (Mirapex) dosage
Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.
- Reference range
- Very low off-label doses; the correct medical starting dose is small (~0.125 mg) — Parkinson's dosing is far higher and NOT the reference hereClinical or reference range, not a personal recommendation.
Pramipexole (Mirapex) half-life
~8-12 hours
Pramipexole (Mirapex) side effects
Nausea, somnolence, dizziness, orthostatic hypotension. Titrate slowly.
- Nausea (dose-limiting — take with food at night)
- Somnolence and sudden sleep onset
- Orthostatic hypotension and dizziness
- Impulse-control effects reported at clinical doses
- Strong nausea
- Sedation/dizziness
- Vivid dreams
- Impulse-control effects
Warnings & monitoring
- Prescription medication — requires a doctor. Harsher acute sides than cabergoline; the Parkinson's dose is much higher and is NOT the prolactin-control dose.
Monitoring: Prolactin labs; strong acute nausea/sedation — titrate slowly.
Preparation & storage
- Storage
- Room temperature, protect from light and moisture.
Commonly stacked with
Track Pramipexole (Mirapex) in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
