SteroidDHT Derivative

Mesterolone (Proviron)

Oral DHT-derived (Mesterolone) — NOT 17aa

Also known as Proviron, mesterolone

Half-life

~12-13 hours

What is Mesterolone (Proviron)?

Oral DHT derivative. Binds SHBG to free up testosterone. AI-like properties without fully blocking aromatase.

How Mesterolone (Proviron) works

DHT-derived oral androgen with strong SHBG binding, increasing free androgen fraction and androgen receptor tone.

Benefits & uses

Lowers SHBG (frees up testosterone)
Mild anti-estrogenic
Libido/wellbeing
Muscle hardness (cosmetic)

Common uses: SHBG reduction, libido, estrogen management on cycle, anti-SHBG effect, mood.

Mesterolone (Proviron) dosage

Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.

Protocol notes: 25-50mg daily oral. Binds SHBG to free up testosterone; mild on-cycle estrogen/libido support. Used in both cycle and PCT contexts (not a standalone PCT).
Commonly reported: Observational; used as an adjunct rather than a primary anabolicObservational use reports — not a recommendation.

Mesterolone (Proviron) half-life

~12-13 hours

Mesterolone (Proviron) side effects

Hair loss if predisposed. Not suitable as PCT standalone. Very mild liver impact.

Hair/prostate androgenic effects
Minimal anabolic benefit alone
HPT suppression at higher doses
Hair loss (DHT-derived, if predisposed)
HPTA suppression (mild vs others)
Not liver-toxic (not 17aa)

Warnings & monitoring

Requires bloodwork + medical monitoring
DHT-derived — hair-loss risk
An adjunct, not a standalone anabolic

Mesterolone (Proviron) interactions

with Testosterone
Compatible · low
Mesterolone (Proviron) is an oral androgen with anti-estrogenic properties and SHBG-lowering effects, increasing free testosterone. Commonly used on cycle to improve libido and lower SHBG.
Timing: Proviron 25–50mg/day throughout cycle
with Testosterone
Compatible
Proviron (Mesterolone) binds SHBG and frees bound testosterone, effectively raising free testosterone levels. Mildly androgenic, no aromatization — a popular addition to testosterone cycles for libido and hardening.
Timing: Proviron 25–50 mg/day oral alongside testosterone cycle

Commonly stacked with

Tamoxifen (Nolvadex)Clomiphene (Clomid)Testosterone Enanthate

Track Mesterolone (Proviron) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.