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VitaminWell-studiedMineral

Manganese

Half-life

~39 days

What is Manganese?

Trace mineral essential for bone formation, metabolism, and manganese superoxide dismutase (MnSOD) production.

How Manganese works

Cofactor for MnSOD (mitochondrial antioxidant enzyme), pyruvate carboxylase, and glycosyltransferases involved in bone matrix formation.

Benefits & uses

  • Antioxidant support
  • Bone formation
  • Metabolism

Common uses: Bone health, antioxidant defense (MnSOD), glucose metabolism, collagen synthesis.

Manganese dosage

Typical dose
1.8–2.3 mg (adequate intake)

Manganese half-life

~39 days (whole body retention)

Manganese side effects

  • Neurotoxicity with excessive occupational exposure (not from supplements)
  • Tremors or Parkinson-like symptoms (chronic overdose — extremely rare)
  • GI upset at high doses
  • Well tolerated from diet/supplements at normal doses

Track Manganese in Protokol.

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More Mineral

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.