Magnesium Threonate
Also known as Magnesium L-Threonate
Half-life
~42 days
What is Magnesium Threonate?
Uniquely crosses the blood-brain barrier. Developed by MIT. Best for cognitive function, sleep, and brain magnesium repletion.
How Magnesium Threonate works
Threonate ligand enables active transport across the blood-brain barrier, increasing cerebrospinal fluid magnesium levels by 15% in animal studies — enhancing synaptic density, NMDA receptor function, and short-term memory formation.
Benefits & uses
- Supports memory & cognition
- Raises brain magnesium
- Sleep support
- Brain magnesium
- Memory/cognition
- Sleep
Common uses: Cognitive enhancement, memory, sleep quality, anxiety, brain magnesium repletion in aging.
Magnesium Threonate dosage
- Typical dose
- 1500–2000 mg Magtein (threonate compound)/day = ~144 mg elemental magnesium. Best taken before bed.
Magnesium Threonate half-life
~42 days (tissue; crosses BBB faster than other forms)
Magnesium Threonate side effects
Sleepiness if taken in the morning. Expensive per-dose. Limited data vs. other forms.
- Sleepiness (intended effect)
- Expensive per-dose compared to glycinate
- Limited head-to-head clinical data vs glycinate
- Generally well tolerated
- Less laxative effect than other forms
- Well tolerated
Track Magnesium Threonate in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
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