SupplementEmergingMetabolic

Inositol

Half-life

~4–6 hours

What is Inositol?

Naturally occurring sugar alcohol involved in cell signaling. Reduces anxiety and improves insulin sensitivity.

How Inositol works

Second messenger in phosphatidylinositol signaling and insulin receptor signaling pathway. Myo-inositol improves ovarian function in PCOS by enhancing FSH receptor sensitivity; D-chiro-inositol acts as insulin sensitizer in peripheral tissues.

Benefits & uses

Insulin sensitivity / blood sugar
PCOS support (with D-chiro-inositol)
Anxiety/mood support
Fertility support

Common uses: Insulin resistance, PCOS management, anxiety/panic disorders, OCD, sleep.

Fat LossRecovery

Inositol dosage

Typical dose: 2–4 g myo-inositol/day. PCOS: 4 g myo-inositol + 400 mcg folate daily. Anxiety/OCD: 12–18 g/day (start low).

Inositol half-life

~4–6 hours (myo-inositol in plasma)

Inositol side effects

GI upset at high doses. Very safe in moderate amounts.

GI nausea, gas, and diarrhea at high doses
Generally very safe
Dose-dependent tolerability
Generally well tolerated
Mild GI at high doses

Track Inositol in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.