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Green Tea Extract (EGCG)

Also known as Green Tea Extract, EGCG

Half-life

~5 hours

What is Green Tea Extract (EGCG)?

Concentrated catechin from green tea. EGCG is the primary bioactive — fat burning, antioxidant, cancer prevention.

How Green Tea Extract (EGCG) works

Inhibits catechol-O-methyltransferase (COMT) to prolong catecholamine activity for fat burning. Activates AMPK, inhibits fatty acid synthase, and has broad antioxidant electron-donating capacity. Synergistic with caffeine for thermogenesis.

Benefits & uses

  • Supports metabolism/fat oxidation
  • Antioxidant
  • May support heart health
  • Mild energy (with caffeine)
  • Potent antioxidant
  • Supports fat oxidation/metabolism
  • Cardiovascular/longevity interest

Common uses: Fat oxidation, antioxidant, metabolic health, cardiovascular protection, neuroprotection.

Fat LossLongevity

Green Tea Extract (EGCG) dosage

Typical dose
200–400 mg EGCG (decaffeinated) daily with food. Avoid high doses on empty stomach.

Green Tea Extract (EGCG) half-life

~5 hours (EGCG plasma)

Green Tea Extract (EGCG) side effects

Caffeine content in non-decaffeinated forms. Liver toxicity at very high doses (>1000 mg/day). Take with food.

  • Hepatotoxicity at very high doses (>1 g/day) or on empty stomach
  • Caffeine content in non-decaffeinated forms
  • Reduces iron absorption — avoid taking with iron-rich foods
  • Generally well tolerated with food
  • Caffeine effects if not decaf
  • Well tolerated with food

Warnings & monitoring

  • High-dose EGCG on an empty stomach has rare liver-toxicity reports — take with food, don't megadose
  • High-dose on an empty stomach linked to rare liver issues — take with food

Track Green Tea Extract (EGCG) in Protokol.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.