TUDCA (Tauroursodeoxycholic Acid)
Also known as TUDCA, TUDCA PCT, tauroursodeoxycholic acid
Half-life
~1–3 hours
What is TUDCA (Tauroursodeoxycholic Acid)?
Bile acid with proven liver-protective and neuroprotective effects. Essential on oral steroid cycles.
How TUDCA (Tauroursodeoxycholic Acid) works
Replaces cytotoxic hydrophobic bile acids in the bile acid pool, reducing hepatocyte endoplasmic reticulum stress and mitochondrial dysfunction. Activates UPR (unfolded protein response) and NF-kB protective pathways. Also protects retinal and neuronal cells.
Benefits & uses
Common uses: Liver protection (oral AAS), bile flow, cholestasis, ER stress reduction, neuroprotection.
TUDCA (Tauroursodeoxycholic Acid) dosage
- Typical dose
- 250–500 mg twice daily with food. On oral AAS: 500 mg twice daily during cycle. Off-label for fatty liver disease.
TUDCA (Tauroursodeoxycholic Acid) half-life
~1–3 hours (plasma TUDCA)
TUDCA (Tauroursodeoxycholic Acid) side effects
GI changes. Very safe even at high doses. Diarrhea possible.
- Loose stools or diarrhea at high doses
- GI cramping if taken on empty stomach
- Overall very safe — UDCA (parent compound) is an FDA-approved drug
TUDCA (Tauroursodeoxycholic Acid) interactions
with Methylated Orals
CompatibleTUDCA reduces ALT/AST elevation from 17α-methylated orals (Anavar, Winstrol, Dianabol) by supporting bile acid flow.
Timing: TUDCA 500mg daily during oral steroid cycles
with NAC
CompatibleNAC supports glutathione/liver detox while TUDCA addresses bile flow — non-overlapping hepatoprotective mechanisms.
Timing: Stack daily during oral AAS cycles
Track TUDCA (Tauroursodeoxycholic Acid) in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
