Medication
Sulfasalazine
Half-life
Parent ~7-15 hours
What is Sulfasalazine?
5-ASA prodrug used for inflammatory bowel disease and rheumatoid disease control.
How Sulfasalazine works
Colonic bacterial cleavage releases anti-inflammatory mesalamine and immunomodulatory sulfapyridine effects.
Sulfasalazine half-life
Parent ~7-15 hours; metabolite sulfapyridine longer
Sulfasalazine side effects
- GI upset
- Rash/hypersensitivity
- Folate depletion and lab monitoring needs
