Medication
Spironolactone
Half-life
Parent ~1
What is Spironolactone?
Mineralocorticoid receptor antagonist with potassium-sparing diuretic and antiandrogen effects.
How Spironolactone works
Blocks aldosterone receptor in distal nephron and antagonizes androgen receptor/5-alpha activity.
Spironolactone half-life
Parent ~1.5 hours; active metabolites ~16-20 hours
Spironolactone side effects
- Hyperkalemia
- Gynecomastia
- Hypotension/dehydration
Spironolactone interactions
with Testosterone
Caution · highSpironolactone is an aldosterone antagonist with potent anti-androgenic properties. It blocks androgen receptors, directly opposing testosterone's mechanism of action. Not used together except in specific transgender hormone protocols.
Timing: Avoid — spironolactone is an anti-androgen that negates testosterone's effects
Track Spironolactone in Protokol.
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