ProtokolPROTOKOL
Supplement

SAMe (S-Adenosyl Methionine)

Half-life

~2-3 hours

What is SAMe (S-Adenosyl Methionine)?

Universal methyl donor — critical for neurotransmitter and membrane synthesis.

How SAMe (S-Adenosyl Methionine) works

Methyl group donor for neurotransmitter (dopamine, serotonin, norepinephrine) synthesis and phosphatidylcholine membrane repair. Activates methyltransferases.

SAMe (S-Adenosyl Methionine) half-life

~2-3 hours (plasma SAMe)

SAMe (S-Adenosyl Methionine) side effects

  • Expensive
  • May cause mild anxiety in some individuals (start low)
  • Interacts with L-DOPA (avoid if on Parkinson's medications)

Track SAMe (S-Adenosyl Methionine) in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.