ProtokolPROTOKOL
Vitamin

Niacinamide (Topical)

Half-life

Local tissue effects hours

What is Niacinamide (Topical)?

Non-flushing niacin form applied as serum or cream for skin. Reduces sebum, rosacea, and strengthens skin barrier.

How Niacinamide (Topical) works

Increases ceramide and free fatty acid synthesis in stratum corneum. Also reduces TEWL (transepidermal water loss) and has weak SIRT1 activation for skin.

Benefits & uses

Common uses: Skin barrier repair, acne control, rosacea reduction, pore refinement, oil regulation.

Niacinamide (Topical) half-life

Local tissue effects hours; systemic ~1-2 hours

Niacinamide (Topical) side effects

  • Mild irritation in very sensitive skin upon first use
  • No systemic side effects
  • Slightly improved tolerance when combined with other skin ingredients

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.