PeptideEmergingMelanocortin
MT-2 (Melanotan II)
Typical dose
250–500 mcg
daily loading, then 1–2×/wk · SubQ
Half-life
30-60 minutes
What is MT-2 (Melanotan II)?
Synthetic analog of alpha-MSH that induces skin pigmentation and reduces UV damage. Also has libido-enhancing effects.
How MT-2 (Melanotan II) works
Activates melanocortin receptors (MC1R for pigmentation, MC3R/MC4R for libido).
Benefits & uses
- Skin tanning
- Libido enhancement
- Appetite suppression
- Fat loss (secondary)
Common uses: Tanning, libido enhancement, erectile function, appetite suppression.
MT-2 (Melanotan II) dosage
- Typical dose
- Typical: loading 250 mcg/day until desired tan, then 250–500 mcg 1–2×/week maintenance. SubQ.
- Protocol notes
- 250-500mcg loading dose, then 500mcg-1mg maintenance. Tanning requires UV exposure.
MT-2 (Melanotan II) half-life
30-60 minutes
MT-2 (Melanotan II) side effects
Nausea (severe initially), facial flushing, spontaneous erections, darkening of moles (monitor), appetite suppression.
- Nausea (severe initially)
- Facial flushing
- Spontaneous erections
- Darkening of moles (monitor)
- Appetite suppression
Warnings & monitoring
- Research use only
- Nausea common especially at higher doses
- Spontaneous erections
- Darkens existing moles — monitor
- Not for use with history of melanoma
Preparation & storage
- Preparation
- Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. A 250 mcg dose = 0.05 mL = 5 units.
- Reconstitution
- Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL. A 250 mcg dose = 0.05 mL = 5 units on a U-100 syringe.
- Storage
- Lyophilized: refrigerate (2–8 °C). Reconstituted: refrigerate, use within 30 days.
